ArticleThe EMBO journal1984
Characterization of bovine keratin genes: similarities of exon patterns in genes coding for different keratins.
Article in The EMBO journal, 1984. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Intermediate filament expression in prostate cancer.Cancer metastasis reviews · 1996Review
- A review of intermediate filament biology and their use in pathologic diagnosis.Molecular biology reports · 1994Review
- Detection of minimal amounts of DNA by electron microscopy using simplified spreading procedures.Chromosoma · 1993Article
- The bovine genome map.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Review
- Enhancer elements directing cell-type-specific expression of cytokeratin genes and changes of the epithelial cytoskeleton by transfections of hybrid cytokeratin genes.The EMBO journal · 1989Article
- The structure and organization of the human heavy neurofilament subunit (NF-H) and the gene encoding it.The EMBO journal · 1988Article
- Differentially expressed bovine cytokeratin genes. Analysis of gene linkage and evolutionary conservation of 5'-upstream sequences.The EMBO journal · 1987Article
- Evolution of keratin genes: different protein domains evolve by different pathways.Journal of molecular evolution · 1987Article
- Evidence for posttranscriptional regulation of the keratins expressed during hyperproliferation and malignant transformation in human epidermis.The Journal of cell biology · 1986Article
- Cytokeratin No. 9, an epidermal type I keratin characteristic of a special program of keratinocyte differentiation displaying body site specificity.The Journal of cell biology · 1986Article
- Amino acid sequence and gene organization of cytokeratin no. 19, an exceptional tail-less intermediate filament protein.The EMBO journal · 1986Article
- Clustered arrangement of keratin intermediate filament genes.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
- In vitro translation of rat liver and Novikoff hepatoma cytokeratin mRNAs.Molecular and cellular biochemistry · 1986Article
- Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes.Molecular and cellular biology · 1986Article
- Organization of cytokeratin bundles by desmosomes in rat mammary cells.The Journal of cell biology · 1986Article
- Complete sequence of a bovine type I cytokeratin gene: conserved and variable intron positions in genes of polypeptides of the same cytokeratin subfamily.The EMBO journal · 1985Article
- The sequence of a type II keratin gene expressed in human skin: conservation of structure among all intermediate filament genes.Proceedings of the National Academy of Sciences of the United States of America · 1985Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Four different genomic clones which contain the genes coding for epidermal keratins Ia (mol. wt. approximately 68 000), Ib (68 000), III (60 000) and VIb (54 500) have been selected using cDNA probes and identified by hybrid-selection translation. The genes vary considerably in length, primarily due to differences in intron sizes: keratin Ia, 9.3 kb (approximately 2.55 kb total exons); keratin Ib, 6.0 kb (2.25 kb exons); keratin III, 6.0 kb (2.2 kb exons); keratin VIb, 4.4 kb (1.85 kb exons). The genes for all three representatives of the basic (type II) cytokeratin subfamily, i.e., keratins Ia, Ib and III, contain eight introns of variable sizes (0.1-1.8 kb) and their exon patterns are very similar. The gene coding for keratin VIb, a representative of the acidic (type I) subfamily, contains seven introns, and the size pattern of its five innermost exons closely resembles that of the genes of the type II keratins. Most of the introns are located in regions coding for the alpha-helical cores of these proteins. Mapping of the intron positions by the S1 nuclease technique and sequencing of some exon-intron boundaries has revealed that some of the introns of all four keratin genes have similar positions to each other and to those of the hamster vimentin gene.(ABSTRACT TRUNCATED AT 250 WORDS)
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