ArticleCell and tissue research1979
The mechanism of microtubule associated cytoplasmic transport. Isolation and preliminary characterisation of a microtubule transport system.
Article in Cell and tissue research, 1979. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 57 citations in OpenAlex.
- Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives.Cells · 2018Article
- Target Based Designing of Anthracenone Derivatives as Tubulin Polymerization Inhibiting Agents: 3D QSAR and Docking Approach.International journal of medicinal chemistry · 2014Article
- Determination of the optimal tubulin isotype target as a method for the development of individualized cancer chemotherapy.Theoretical biology & medical modelling · 2013Article
- The roles of beta-tubulin mutations and isotype expression in acquired drug resistance.Cancer informatics · 2007Article
- Homology modeling of tubulin: influence predictions for microtubule's biophysical properties.European biophysics journal : EBJ · 2006Article
- Reorganisation of microtubule arrays in the telotrophic ovaries of hemipteran insects: Correlation with meiotic reinitiation.Roux's archives of developmental biology : the official organ of the EDBO · 1995Article
- Movement of mitochondria in the ovarian trophic cord of Dysdercus intermedius (Heteroptera) resembles nerve axonal transport.Roux's archives of developmental biology : the official organ of the EDBO · 1987Article
- Voltage gradients and microtubules both involved in intercellular protein and mitochondria transport in the telotrophic ovariole of Dysdercus intermedius.Roux's archives of developmental biology : the official organ of the EDBO · 1987Article
- The role of microtubules in the differentiation of ovarian follicles during vitellogenesis inDrosophila.Roux's archives of developmental biology : the official organ of the EDBO · 1986Article
- Firm structural associations between migratory pigment granules and microtubules in crayfish retinula cells.The Journal of cell biology · 1983Article
- Microtubule polarity in the nutritive tubes of insect ovarioles.Cell and tissue research · 1983Article
- The nature of the clear zone around microtubules.Cell and tissue research · 1982Article
- Observations on cytoplasmic transport along ovarian nutritive tubes of polyphagous coleopterans.Cell and tissue research · 1981Article
- The mechanism of microtubule associated cytoplasmic transport. Isolation and preliminary characterisation of a microtubule transport system.Cell and tissue research · 1979Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nutritive tubes of telotrophic insect ovaries are cytoplasmic channels along which ribosomes are transported over distances of several mm from trophic cells to the developing oocytes. The presence within the nutritive tubes of a massive number of orientated microtubules renders them strongly birefringent in polarised light, a property which, together with their size, rendered them amenable to isolation by microdissection. Ultrastructurally the isolated tubes were indistinguishable from undissected controls. Polyacrylamide gels revealed a consistent pattern of some 30 bands of which tubulin was the most prominent. The tubes also contained a band which comigrated with the major high molecular weight microtubule associated protein (MAP) from mouse brain but no detectable actin, myosin or dynein. Microtubules in the isolated tubes were not depolymerised by treatments (cold, calcium and colchicine) which typically disrupt cytoplasmic microtubules. Following extraction of the membrane enclosing the tubes and the cytoplasmic matrix the microtubule cytoskeleton persisted, retaining its cylindrical organisation although no bridges between the microtubules were detected in the electron microscope. The possibility that the stability and spatial deployment of the nutritive tube microtubules is conferred by specific microtubule accessory proteins is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.