ArticleGut1971
47 Calcium abosrption in parenchymatous and biliary liver disease.
Article in Gut, 1971. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 49 citations in OpenAlex.
- Nutritional deficiencies after bariatric surgery.Nature reviews. Endocrinology · 2012Review
- Review
- Perspective in liver disease: An Irish experience.Irish journal of medical science · 1979Article
- Article
- Intestinal absorption of cholecalciferol in alcoholic liver disease and primary biliary cirrhosis.Gut · 1979Article
- Article
- Hyperparathyroidism in hepatobiliary disease in infancy.European journal of pediatrics · 1975Article
- Metabolic bone diseases and chronic liver disease.Irish journal of medical science · 1974Article
- Intestinal absorption of calcium and magnesium in hepatobiliary disease in infancy.Archives of disease in childhood · 1974Article
- [Calcium absorption in health and disease. II. Syndromes of imparied calcium absorption (author's transl)].Klinische Wochenschrift · 1974Review
- Bone disease in infants with prolonged obstructive jaundice.Pediatric radiology · 1974Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As measured by whole body retention of isotopic calcium given in milk, absorption of calcium was impaired in 10 patients with chronic parenchymal non-biliary liver disease who were icteric. Mean absorption was normal in 15 patients with parenchymal liver disease who were anicteric although some individual patients absorbed less than any of the controls. Depressed absorption of calcium was seen in 10 patients with primary biliary cirrhosis and seven patients with intra- or extra-hepatic biliary obstructive disease. The most likely cause for this malabsorption is reduced bile salt secretion into the intestinal lumen which impairs vitamin D and fat absorption. The finding that parenteral vitamin D increased calcium absorption to normal levels in five patients with primary biliary cirrhosis suggests that deficiency of this vitamin is a major and correctable factor leading to calcium malabsorption in such patients. Precipitation of calcium salts by excess intraluminal fat appears to be a further possible factor reducing calcium absorption in these patients. These findings emphasize the importance of parenteral vitamin D therapy in patients with chronic obstructive biliary diseases. They also suggest that certain patients with chronic parenchymatous liver disease, particularly those who are icteric, may also occasionally require therapy with vitamin D.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.