ArticleArchives of oto-rhino-laryngology1979
The fate of hemidesmosomes in laryngeal carcinoma.
Article in Archives of oto-rhino-laryngology, 1979. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Hemidesmosome-Related Keratin Filament Bundling and Nucleation.International journal of molecular sciences · 2021Article
- EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion.The Journal of cell biology · 2001Article
- Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes.The EMBO journal · 1995Article
- Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion.The Journal of cell biology · 1991Article
- Intracytoplasmic desmosomes in malignant keratinocytes of laryngeal carcinoma.Archives of oto-rhino-laryngology · 1980Article
- Gap junctions in laryngeal carcinoma.Archives of oto-rhino-laryngology · 1980Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ultrastructural morphology of the hemidesmosomes in malignant epithelial cells of invasive squamous cell carcinoma of the human larynx was studied by electron microscopy. In the more advanced carcinomas the hemidesmosomes are reduced in number or absent over extensive areas of the epithelial stromal junction. In some places the hemidesmosomes are observed to be in the process of being dislodged from their normal sites at the plasma membrane of the basal carcinoma cell. After dislodgment from the basal plasmalemma into the subepithelial connective tissue the hemidesmosomes are seen to round off with the cytoplasmic attachment plaques lying on their inner circumference. A constant feature of the detached hemidesmosomes is the absence of inserting tonofilaments. Frequently, the detached hemidesmosomes are found to be in close association with detached multilayered basement membrane material in the stroma. The detached hemidesmosome-structures appear to migrate down into the deeper layers of the connective tissue space apparently loosing their distinct ultrastructure. These observations indicate that the detachment of hemidesmosomes and their subsequent downward dermal migration may result in a loss of epithelial-stromal adherence in invasive epithelial cancer of the larynx.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.