ReviewBone research2026
Satellite cell attrition and skeletal muscle aging.
Review in Bone research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle aging involves the progressive decline in mass and function of muscle tissue, significantly impacting mobility and quality of life in older adults. Central to this process is the functional deterioration of SCs, the primary muscle stem cells responsible for regeneration. Aging impairs SC self-renewal, activation, proliferation, and differentiation through mechanisms including telomere attrition, mitochondrial dysfunction, epigenetic dysregulation, and aberrant signaling pathways such as Notch/Wnt and TGF-β. Additionally, the aged microenvironment-marked by chronic inflammation, oxidative stress, fibro-adipogenic infiltration, immune dysregulation, and vascular decline-further suppresses SC activity. Recent advances in multidisciplinary research, encompassing single-cell genomics, epigenetics, and bioengineering, have deepened our understanding of these mechanisms. Emerging interventions, such as nutritional strategies, exercise, pharmacological agents, cell therapy, and gene editing, offer promising avenues for restoring SC function and rejuvenating muscle regeneration. Future efforts should focus on integrated, personalized approaches to combat sarcopenia and improve healthspan.
Indexed as
Identifiers
43026284What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.