ArticleMethods in molecular biology (Clifton, N.J.)2027
Guide to Extending Findings from Selected Samples Using Inverse Odds of Selection Weights.
Article in Methods in molecular biology (Clifton, N.J.), 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
When study samples, such as randomized controlled trial participants or individuals in biomarker studies, come from highly selected groups, results may not generalize to broader populations. Statistical methods called transportability methods enable extension of findings from such samples to specified target populations under certain assumptions. Here, we describe the implementation of one transportability method, inverse odds of selection weighting, to extend findings from selected trial samples. We discuss assumptions and data requirements, including harmonization and concatenation of trial and target datasets, and describe estimation, evaluation, and application of inverse odds of selection weights. Throughout, we highlight practical considerations and commonly encountered challenges.
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