ReviewMetabolism open2026
Beyond brown adipose tissue: Avian thermogenesis without UCP1 - mechanisms, evidence gaps and implications for metabolic health and sustainable poultry production.
Review in Metabolism open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
1 author.
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Abstract
Unlike mammals, birds lack canonical brown adipose tissue and the UCP1 gene, yet exhibit UCP1-independent non-shivering thermogenesis (NST). In vitro, embryonic chicken mesenchymal cells differentiate into avian brown adipocyte-like cells (ABALCs) with multilocular lipid droplets, elevated mitochondrial density, and upregulated PGC-1α and PPARγ, activating a transfected mouse UCP1 promoter despite endogenous UCP1 loss. In vivo, gradual cold acclimatization or triiodothyronine (T
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