Evidence map›Paper›PMID 43022537›Full record

ArticleACS omega2026

Deciphering the Material Basis of an Herbal Formula via Integrated Two-dimensional Chromatography, In Silico Screening, and Comparative Pharmacokinetics: A Case Study of Kaiyu Jiangzhuo Formula.

Nanqi Hou, Qinjing Xia, Zuoyang Li, Xinyue Cao, Zichen Tian, Yuying Zhou, Zepeng Zhang, Kai Yin, Shilei Wang, Dandan Si and 4 more

Abstract read
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In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nanqi HouDepartment of Endocrinology, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, China.
Qinjing XiaNortheast Asia Research Institute of Traditional Chinese Medicine, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China.
Zuoyang LiNortheast Asia Research Institute of Traditional Chinese Medicine, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China.
Xinyue CaoNortheast Asia Research Institute of Traditional Chinese Medicine, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China.
Zichen TianDepartment of Endocrinology, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, China.
Yuying ZhouDepartment of Endocrinology, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, China.
Zepeng ZhangResearch Center of Traditional Chinese Medicine, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin 130021, China.
Kai YinDepartment of Endocrinology, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, China.
Shilei WangNortheast Asia Research Institute of Traditional Chinese Medicine, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China.
Dandan SiSciex China, Beijing 100015, China.
Zhuo ManSciex China, Beijing 100015, China.
Xiaolin TongNortheast Asia Research Institute of Traditional Chinese Medicine, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, China.
Hang SuDepartment of Endocrinology, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, China.ORCID https://orcid.org/0000-0003-3030-0509
Xiangyan LiDepartment of Endocrinology, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, China.ORCID https://orcid.org/0000-0001-6780-6314

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kaiyu Jiangzhuo (KYJZ) is a Chinese medicine formula composed of nine herbs. Its efficacy in alleviating glycolipid metabolic disorders and reducing the incidence of diabetes mellitus in overweight patients with prediabetes has been widely validated. Although our previous studies separately characterized the chemical constituents of the KYJZ decoction and the components detected in plasma, the relationship between chemical profiling and systemic exposure remains undefined. In particular, it is unclear which decoction constituents are absorbed into systemic circulation and how obesity modulates their pharmacokinetic profiles. This study aimed to comprehensively profile the components of KYJZ and identify potential bioactive constituents by integrating

Identifiers

PMID43022537
PMCPMC13756683

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.