ReviewNature aging2026
Social determinants of health and the exposome shape aging and dementia across global populations.
Review in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social determinants of health, the conditions in which people are born, grow, live, work and age, shape brain aging and dementia. Yet evidence is dominated by Global North populations and often relies on single indicators (for example, education or income), limiting risk characterization and generalizability across settings. This Perspective provides a global, integrative overview of multidimensional, multilevel and life-course approaches to social determinants of health and exposome research in brain health. We examine composite indices and social-exposomal factors, their need for harmonization, contextual adaptation and local validation, and biological embedding through stress-related, inflammatory, metabolic, vascular and epigenetic pathways. We also discuss interactions with genetic susceptibility and the analytical challenges of modeling cumulative, time-varying and nonlinear exposures. These advances require feasible, policy-relevant implementation in resource-constrained settings. Moving beyond static, single-domain proxies towards context-sensitive measures and multilevel designs can improve risk characterization and support more equitable, globally relevant strategies for dementia prevention and precision public health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.