ArticleRevista da Associacao Medica Brasileira (1992)2026
Triglyceride-glucose index and its derivatives in women with polyendocrine metabolic ovarian syndrome: associations with insulin resistance markers.
Article in Revista da Associacao Medica Brasileira (1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe aim of this study was to compare the triglyceride-glucose index and its derivatives between women with polyendocrine metabolic ovarian syndrome and healthy controls and to examine their associations with established fasting-based surrogate markers of insulin resistance.
methodsThe final analytical cohort consisted of 109 women with polyendocrine metabolic ovarian syndrome and 91 healthy controls. Homeostasis model assessment of insulin resistance, quantitative insulin sensitivity check index, fasting glucose-to-insulin ratio, triglyceride-glucose index, triglyceride-glucose-body mass index, and triglyceride-to-high-density lipoprotein cholesterol ratio were calculated. Between-group comparisons and correlation analyses were performed, with age, body mass index, and waist circumference considered in adjusted analyses.
resultsWomen with polyendocrine metabolic ovarian syndrome had significantly higher homeostasis model assessment of insulin resistance values than healthy controls [median: 3.66 (range: 0.76-37.72) vs. 0.86 (range: 0.30-2.70), p<0.001]. The between-group difference in the triglyceride-glucose index remained significant after adjustment for age, body mass index, and waist circumference (F=20.489, p<0.001, ηp2=0.094). Within the polyendocrine metabolic ovarian syndrome group, triglyceride-glucose was positively correlated with homeostasis model assessment of insulin resistance (r=0.505, p<0.001) and negatively correlated with quantitative insulin sensitivity check index (r=-0.505, p<0.001) and fasting glucose-to-insulin ratio (r=-0.449, p<0.001).
conclusionTriglyceride-glucose and triglyceride-glucose-body mass index were higher in women with polyendocrine metabolic ovarian syndrome than in healthy controls and were associated with fasting-based surrogate measures of insulin resistance. These findings suggest that triglyceride-glucose-based indices may provide complementary information regarding the metabolic profile associated with polyendocrine metabolic ovarian syndrome. Their clinical utility requires further validation in prospective studies using direct measures of insulin sensitivity.
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