Osteopontin influences weight gain and immune cell composition during ART-treated chronic HIV infection.

Elijah H Davis, Jasmine Wangui, Catalina Argandona Lopez, Aynur Shirmamedova, Amanda M Brown

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elijah H DavisDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Jasmine WanguiDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Catalina Argandona LopezDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Aynur ShirmamedovaDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Amanda M BrownDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Funding

The HIV-Osteopontin-HAND Triad: Inflammation and Neuronal Injury in the BrainR01NS102006 · NINDS · JOHNS HOPKINS UNIVERSITY · PI AMANDA MARIA BROWN · 2016 to 2026

$6.4M

NINDS NIH HHS R01 NS102006

6 · The paper itself

Abstract

Despite the ability of antiretroviral therapy (ART) to effectively suppress but not cure, human immunodeficiency virus type 1 (HIV), people with HIV (PWH) remain at increased risk for metabolic and inflammatory comorbidities that worsen with age. Here, we identify osteopontin (OPN) as a modulator of weight change in a humanized HIV-infected mouse model of ART-treated, chronic infection. Knockdown of OPN (OPN

Indexed as

antiretroviral therapyhumanized micemetabolismmonocytessecreted phosphoprotein-1sex differences

Identifiers

PMID43017491

DOI10.1016/j.isci.2026.118089

PMCPMC13753361

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.