ArticleFrontiers in medicine2026
Multidimensional analysis explores the correlation and potential molecular mechanisms between serum uric acid and risk of gastric cancer.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the causal association between SUA and gastric cancer risk and elucidate the underlying biological mechanisms. Methods: A two-sample Mendelian randomization (MR) design was adopted. The inverse-variance weighted (IVW) method served as the primary analysis, supplemented by MR-Egger, weighted median, simple mode and weighted mode methods. Sensitivity analyses included the MR-Egger intercept test for horizontal pleiotropy, Cochran's Results: Genetically elevated SUA was causally associated with reduced gastric cancer risk in the IVW analysis (OR = 0.76, 95% CI: 0.62-0.92, Conclusions: SUA exerts a protective causal effect against gastric cancer. The anti-tumor effect is mechanistically driven by oxidative stress induction and PI3K/AKT pathway inhibition, with SNP-associated genes linked to gastric cancer progression via metabolism-related signaling pathways.
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