Evidence map›Paper›PMID 43016959›Full record

ReviewBiophysical reviews2026

The rise of state-centric biophysics: integrating orthogonal molecular readouts across biophysical scales.

Paulo Roberto Dores-Silva, Todd Willian Pascarella, Jason Michael Newman, Júlio César Borges

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biophysical reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paulo Roberto Dores-SilvaSão Carlos Institute of Chemistry, University of São Paulo, São Carlos, SP 13566-590 Brazil.ORCID 0000-0001-8656-7769
Todd Willian PascarellaValenthos Biophysics, 1740 Robinson Ave, San Diego, CA 92103 USA.
Jason Michael NewmanValenthos Biophysics, 1740 Robinson Ave, San Diego, CA 92103 USA.
Júlio César BorgesSão Carlos Institute of Chemistry, University of São Paulo, São Carlos, SP 13566-590 Brazil.ORCID 0000-0003-4856-748X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modern biophysics has evolved from the measurement of isolated molecular properties toward increasingly integrated molecular characterization. Advances in instrumentation, orthogonal workflows, and multidimensional analytical platforms have expanded the breadth of molecular information obtainable from a single experimental context, increasing what we define here as "information density". In this review, we examine the scientific and technological forces underlying this transition and propose Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s12551-026-01452-9.

Indexed as

Information densityIntegrated biophysical platformsMultidimensional molecular characterizationState-centric biophysics

Identifiers

PMID43016959
PMCPMC13751992

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.