ArticleAdvanced functional materials2026
Dynamic Matrix Stiffening Reprograms Endothelial Angiogenic Remodeling via
Article in Advanced functional materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Progressive stiffening of the extracellular matrix (ECM) is a hallmark of vascular aging and fibrosis. Stiffening the ECM disrupts endothelial adherens junctions and barrier function, but whether endothelial cells impact pericellular ECM, which in turn affects endothelial cell fate, remains unclear. Here, we use a phototunable collagen-hyaluronic acid hydrogel to impose in situ stiffening around endothelial colony-forming cells (ECFCs). In compliant matrices, ECFCs realigned collagen fibers, generated pericellular stiffening, and deposited nascent protein in spatial register with reorganized collagen. Dynamic stiffening disrupted this local feedback, with collagen alignment and pericellular stiffening suppressed despite unchanged collagen density, while nascent protein deposition increased but became uncoupled from constructive remodeling. Transcriptomic profiling revealed a shift from angiogenic, matrix-constructive programs toward stress-adaptive states. We identify
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