Evidence map›Paper›PMID 43011743›Full record

ReviewFrontiers in physiology2026

Applications and mechanisms of therapeutic ultrasound in skin repair and regeneration.

Zeyu He, Shiwen Shao, Yi Fang, Xuegang Xu, Gaosen Zhang

Abstract readReview
In one paragraph

Review in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zeyu He *Department of Dermatology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Shiwen Shao *Department of Dermatology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Yi FangDepartment of Ultrasound, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Xuegang XuDepartment of Dermatology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Gaosen ZhangDepartment of Ultrasound, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultrasound modulates cellular and tissue processes underlying skin repair and regeneration via thermal and mechanical effects, including cavitation, and can act as an external trigger to facilitate transdermal delivery or activate ultrasound-responsive materials. This review summarizes the acoustic fundamentals and Mechanotransduction pathways of different types of ultrasounds, as well as research advances in wound healing, pathological scar intervention, skin tissue remodeling, skin appendage regeneration, and synergistic applications with ultrasound-responsive materials. Emphasis is placed on the molecular and cellular mechanisms by which ultrasound regulates inflammatory responses, angiogenesis, re-epithelialization, and extracellular matrix remodeling. Currently, apart from studies on focused ultrasound and ultrasound-assisted wound therapy, most supporting evidence is derived from

Indexed as

mechanotransductionskin regenerationtherapeutic ultrasoundtransdermal deliveryultrasound-responsive biomaterials

Identifiers

PMID43011743
PMCPMC13749164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.