Evidence map›Paper›PMID 43011693›Full record

ArticlemicroPublication biology2026

Preserved eHSP70-to-iHSP70 Ratio Masks a Functional Role of HSP70 in Vascular Hypercontractility in Female Diabetic Mice.

Valentina Ochoa Mendoza, Swasti Rastogi, Chloe Biby, Jessica Liaw, Kenia Pedrosa Nunes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in microPublication biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Valentina Ochoa MendozaBiomedical Engineering and Science, Laboratory of Vascular Biology, Florida Institute of Technology, Melbourne, FL, US.
Swasti RastogiBiomedical Engineering and Science, Laboratory of Vascular Biology, Florida Institute of Technology, Melbourne, FL, US.
Chloe BibyBiomedical Engineering and Science, Laboratory of Vascular Biology, Florida Institute of Technology, Melbourne, FL, US.
Jessica LiawBiomedical Engineering and Science, Laboratory of Vascular Biology, Florida Institute of Technology, Melbourne, FL, US.
Kenia Pedrosa NunesBiomedical Engineering and Science, Laboratory of Vascular Biology, Florida Institute of Technology, Melbourne, FL, US.

Funding

Dual Role of HSP70 in Diabetes-Induced Vascular DysfunctionR15DK131511 · NIDDK · FLORIDA INSTITUTE OF TECHNOLOGY · PI NUNES, KENIA PEDROSA · 2022 to 2022
$434k
NIDDK NIH HHS R15 DK131511
6 · The paper itself

Abstract

Heat Shock Protein 70 (HSP70) has emerged as a modulator of vascular behavior, and its physiological role is sex- and age-dependent. In diabetic conditions, pharmacological blockade of HSP70 improves the vasculature in males. Yet, in diabetic females, the HSP70 profile and its role in vascular hypercontractility, a hallmark of type 2 diabetes (T2D), remain unknown. We showed that inhibiting aortic HSP70 in T2D females ameliorates vascular dysfunction, while the eHSP70-to-iHSP70 ratio is preserved, suggesting sex-specific differences during T2D.

Identifiers

PMID43011693
PMCPMC13749085

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.