ArticleCirculation reports2026
Association Between High-Density Lipoprotein Cholesterol Efflux Capacity and Renal Function in Patients With Type 2 Diabetes.
Article in Circulation reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Background: The cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) (HDL-CEC) is inversely associated with atherosclerotic cardiovascular disease. Type 2 diabetes mellitus (T2DM) is frequently complicated by chronic kidney disease (CKD), usually associated with increased homocysteine (Hcy), and these conditions are likely to be involved in HDL dysfunction. However, the relationship between HDL-CEC and CKD, as well as Hcy levels in patients with T2DM remains unclear. Methods and Results: This cross-sectional study involved 138 patients with T2DM. CEC was measured using a stable-isotope method with J774 macrophage-like cells and apolipoprotein B-depleted serum. Multiple regression analysis showed that sex (β=0.278; P=0.005), estimated glomerular filtration rate (eGFR; β=0.232; P=0.038), and HDL cholesterol (HDL-C; β=0.197; P=0.030) were independently associated with CEC. Conclusions: Sex, eGFR, and HDL-C were independently associated with HDL-CEC in patients with T2DM. These findings suggest that impaired renal function may be related to impaired HDL function in this population, although causal relationships cannot be inferred from this cross-sectional analysis.
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