Evidence map›Paper›PMID 43005478›Full record

ArticleAdvanced pharmaceutical bulletin2026

Sericin Improves Cognitive Outcomes in a Mouse Model of Cerebral Ischemia: The Role of Blood-Brain Barrier Disruption and Edema.

Leila Hosseini, Seyed Mehdi Vatandoust, Narmin Farazi, Amir Pasokh, Saeed Sadigh-Eteghad, Mohammad Farzipour, Fereshteh Farajdokht, Alireza Mohajjel Nayebi, Ali Hassanzadeh, Javad Mahmoudi

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Article in Advanced pharmaceutical bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leila HosseiniResearch Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-4203-4618
Seyed Mehdi VatandoustNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Narmin FaraziNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Amir PasokhNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Saeed Sadigh-EteghadNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad FarzipourNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Fereshteh FarajdokhtNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Alireza Mohajjel NayebiDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Ali HassanzadehDepartment of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Javad MahmoudiNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0001-9755-9422

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Oxidative stress, edema, and blood-brain barrier (BBB) dysfunction are involved in the pathophysiology of stroke and may offer opportunities for managing its related insults. Sericin (Ser) has neuroprotective and pro-cognitive effects. This study aimed to determine whether Ser could reduce cerebral edema and its associated molecular and cognitive abnormalities in a mouse model of cortical ischemia. Methods: The mice were allocated into five cohorts: Sham, normal saline (NS), Ser200, Ser300, and Ser400. Each group received its treatment for 14 days before being subjected to cerebral ischemia or a sham surgery procedure. Spatial memory was assessed using the Lashley III maze. Brain edema, BBB permeability, malondialdehyde (MDA) level, and changes in anti-oxidant markers (total antioxidant capacity (TAC), as well as superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities) were evaluated in the brain samples. Additionally, the expression of BBB structural integrity proteins, including occludin and zonula occludens-1 (ZO-1), and matrix metalloproteinase-9 (MMP-9), were analyzed. Results: Ser300 and Ser400 improved spatial memory (at least Conclusion: Ser improved cognitive dysfunction associated with BBB damage and edema induced by cerebral ischemia in a mouse model.

Indexed as

Blood-brain barrierBrain edemaMemoryOxidative stressPhotothrombotic strokeSericin

Identifiers

PMID43005478
PMCPMC13745743

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.