ArticleNutrition & metabolism2026
Associations of grip strength, muscle mass, and fat-to-muscle ratio with advanced cardiovascular-kidney-metabolic syndrome in chinese community adults.
Article in Nutrition & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundCardiovascular-kidney-metabolic (CKM) syndrome is a global health challenge. However, few studies have explored the associations between muscle health and CKM syndrome. This study aimed to investigate the associations between appendicular skeletal muscle mass (ASM), grip strength, and fat-to-muscle ratio (FMR) and advanced CKM syndrome in a Chinese community-based population.
methodsWe conducted an observational study involving 7,330 Chinese adults. CKM syndrome is categorized into five stages, with stages 3-4 defined as advanced CKM syndrome. An electronic dynamometer and bioelectrical impedance analysis were used to measure grip strength, ASM, and FMR. The FMR was calculated as fat mass divided by muscle mass, and ASM/BMI as ASM divided by body mass index (BMI). Associations of grip strength, ASM/BMI, and FMR with advanced CKM syndrome were assessed using multivariable logistic regression, with subgroup analyses by age and sex. Subgroup analyses were further conducted to explore potential interactions.
resultsAdvanced CKM syndrome was identified in 8.57% of participants. Higher ASM/BMI (Q4 vs. Q1: OR = 0.26, 95% CI: 0.15-0.45) and grip strength (Q4 vs. Q1: OR = 0.42, 95% CI: 0.30-0.59) were inversely linked to the likelihood of having advanced CKM syndrome (P-trend < 0.001). Conversely, a higher FMR was associated with higher odds of advanced CKM syndrome (Q4 vs. Q1: OR = 2.22, 95% CI: 1.26-3.89; P-trend < 0.05). Furthermore, subgroup analyses showed that the inverse association between grip strength and advanced CKM syndrome was stronger among females (P for interaction = 0.007). A nonlinear, L-shaped association was observed between grip strength and advanced CKM syndrome, with an inflection point at 26.2 kg in females.
conclusionsLower ASM/BMI and grip strength, and a higher FMR are associated with an increased likelihood of advanced CKM syndrome. Additionally, a plausible grip-strength threshold (~ 26.2 kg) was identified among females. These findings support evaluating muscle health for risk stratification in CKM syndrome.
trial registrationRegistry http//www.chictr.org.cn/, TRN ChiCTR2100054130, Registration date 9 December, 2021.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.