Trial reportCardiovascular diabetology2026
Influence of diabetes mellitus on dapagliflozin response after transcatheter aortic valve replacement (TAVR): insights from the DAPA-TAVI trial.
Trial report in Cardiovascular diabetology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors.
Funding
Abstract
backgroundThe DAPA-TAVI trial demonstrated that dapagliflozin reduced the composite of all-cause mortality or worsening heart failure (HF) at 1 year in patients undergoing transcatheter aortic valve replacement (TAVR) with prior HF. Whether the magnitude of this benefit differs according to diabetes mellitus (DM) status remains uncertain.
methodsThis pre-specified subgroup analysis of the multicenter randomized DAPA-TAVI trial conducted at 39 centers in Spain, which enrolled 1222 patients with severe aortic stenosis undergoing TAVR with prior HF and at least one high-risk condition. Patients were stratified by the presence or absence of DM. The primary endpoint was a composite of all-cause mortality or worsening HF at 12 months. Secondary endpoints included the individual components of the primary endpoint, cardiovascular death, and safety outcomes. Cox proportional-hazards models adjusted for age, sex, coronary artery disease, baseline ejection fraction and baseline estimated glomerular filtration rate were used to estimate treatment effects.
resultsAmong 1222 patients, 537 (43.9%) had DM. In patients with DM, dapagliflozin significantly reduced the primary endpoint compared with standard care (15.2% vs. 22.7%; HR 0.580; 95% CI 0.389-0.866; p = 0.008; number needed to treat [NNT] = 11), driven primarily by fewer worsening HF events. In patients without DM, the reduction was numerically lower and non-significant (15.0% vs. 18.0%; HR 0.814; 95% CI 0.560-1.183; p = 0.280; NNT = 32). Genital infections were more frequent with dapagliflozin in patients with DM, whereas symptomatic hypotension was more common in those without DM. No significant differences in serious adverse events were observed in either subgroup. No statistically significant interactions between DM status and treatment effect were observed for the primary or secondary endpoints.
conclusionsIn this pre-specified subanalysis of the DAPA-TAVI trial, dapagliflozin significantly reduced the risk of death or worsening HF in patients with DM undergoing TAVR, with a favorable benefit-risk profile, whereas a more modest and non-significant effect was observed in non-DM patients. Although no statistically significant interaction according to diabetes status was observed, the apparently greater benefit among patients with DM warrants further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.