ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Developing the World-Wide FINGERS biorepository for dementia risk reduction trials.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionDementia prevention research increasingly uses multimodal interventions. Harmonized biomarker practices are essential to enable comparable cross-population analysis with initiatives such as the World-Wide FINGERS (WW-FINGERS) network contributing to this effort.
methodsTo advance globally representative biomarker research in dementia prevention trials, we conducted a cross-sectional, network-wide survey of WW-FINGERS teams assessing biospecimen collection, processing and storage, biomarker measurements, and readiness for harmonized procedures.
resultsMost studies (30/39) had or were developing biorepositories; four planned collection and five had none. Practices were broadly aligned, but remaining variability highlights priority targets for harmonization. Clinical biomarkers (lipids, glucose, liver/kidney function) were obtained even in lower-resourced settings. Many studies measured Alzheimer's disease and related dementias (ADRD) biomarkers (blood-based amyloid/tau and neurodegeneration; cerebrospinal fluid where feasible) and increasingly used multi-omics platforms. Evidence-based preanalytical guidance were provided.
conclusionThe WW-FINGERS biorepository provides a world-first platform for harmonized biomarker discovery across diverse populations in dementia prevention, helping to reduce inequities in research participation, accelerating globally representative strategies.
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