ArticleInternational journal of cardiology. Heart & vasculature2026
Adiposity and glycemic patterns among adults meeting measured cardiovascular-kidney-metabolic stage 1 criteria: a multicohort study.
Article in International journal of cardiology. Heart & vasculature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The 2026 AHA/ACC/ADA/ASN guideline defines cardiovascular-kidney-metabolic (CKM) stage 1 by excess or dysfunctional adiposity. Whether adiposity and glycemic patterns distinguish subsequent risk is uncertain. Methods: Adults aged 45-79 years meeting measured stage 1 criteria were studied in CHARLS and CHNS. Four patterns combined body mass index (BMI), waist circumference, and prediabetes. Modified Poisson models estimated risk ratios (RRs). Progression and hypertension models used censoring weights; cumulative self-reported cardiovascular disease (CVD) models used baseline-covariate imputation. The nonglycemic composite was a key secondary outcome. NHANES assessed reclassification with ancestry-appropriate thresholds and age-sex standardization. Chinese cohorts lacked albuminuria and subclinical CVD assessment. Results: In CHARLS (model Conclusions: Adiposity and glycemic patterns identified prognostic heterogeneity among adults meeting measured CKM stage 1 criteria, supporting joint assessment of these features.
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