Urolithin A and its dietary precursors: mechanisms underlying the improvement of cognitive dysfunction.

Jiale Du, Wei Yang, Jiatong Liu, Han Dong

Abstract readReview

In one paragraph

Review in Nutrition & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Jiale DuDepartment of Geriatrics, Jilin Geriatrics Clinical Research Center, The First Hospital of Jilin University, Changchun, 130012, Jilin, China.

Wei YangDepartment of Ophthalmology, The First Hospital of Jilin University, Changchun, 130012, Jilin, China.

Jiatong LiuDepartment of Geriatrics, Jilin Geriatrics Clinical Research Center, The First Hospital of Jilin University, Changchun, 130012, Jilin, China.

Han DongDepartment of Geriatrics, Jilin Geriatrics Clinical Research Center, The First Hospital of Jilin University, Changchun, 130012, Jilin, China. donghan@jlu.edu.cn.

Funding

Natural Science Foundation of Jilin Province YDZJ202401213ZYTSSpecial project for Medical and Health Talents of Jilin Province JLSRCZX2026-93

6 · The paper itself

Abstract

Cognitive dysfunction, driven by psychiatric and functional factors, toxic factors, neurodegenerative diseases and cerebrovascular diseases, metabolic diseases, and other systemic diseases, represents a significant global health challenge with limited pharmacological interventions. Emerging evidence highlights Urolithin A (UroA)-a gut microbiota-derived polyphenol of dietary ellagitannins (ETs) and ellagic acid (EA) -as a highly promising neuroprotective candidate. Current research has found that UroA and its derivatives have an effect against cognitive dysfunction. However, there is currently a lack of comprehensive reviews. This review provides a comprehensive insight of aetiology and pathogenesis of cognitive dysfunction, with a specific focus on how UroA and its precursors intercept these pathological trajectories, while evaluating the source and metabolism of Urolithin A. And we deeply dissect its mechanisms against cognitive dysfunction, particularly its capacity to mitigate neuroinflammation, restore autophagy, modulate the gur-brain axis and so on. Moreover, we address current knowledge gaps and focus on future perspectives.

Indexed as

Anti-neuroinflammationAutophagyCognitive dysfunctionGut-brain axisUrolithin A

Identifiers

PMID43000381

DOI10.1186/s12986-026-01185-2

PMCPMC13746510

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.