SynthesisAmerican journal of cardiovascular drugs : drugs, devices, and other interventions2026
Association Between Colchicine Use and Clinical Outcomes Post Cardiac Surgery: A Meta-analysis of Randomized Controlled Trials.
Synthesis in American journal of cardiovascular drugs : drugs, devices, and other interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColchicine has been shown to mitigate inflammation and reduce adverse cardiovascular events. However, evidence from clinical trials has been mixed regarding its efficacy in cardiovascular prevention among patients undergoing cardiac surgery.
objectiveWe aimed to evaluate the association between colchicine use and cardiovascular outcomes in patients undergoing cardiac surgery.
methodsWe conducted a systematic literature search on various electronic databases for relevant studies from their inception until July 15, 2025. Randomized controlled trials (RCTs) with two arms-one with colchicine as an intervention and the other with placebo-in patients undergoing cardiac surgery were included. Risk ratios (RRs) and weighted mean differences (WMDs), along with 95% confidence intervals (CIs), were pooled using a random-effects model. A p value of < 0.05 was considered statistically significant.
resultsNine RCTs with 2005 patients (990 in the colchicine group and 1015 in the placebo group) were included. The mean age was 62.8 years. Pooled analysis demonstrated that compared with placebo, colchicine was significantly associated with a reduction in the risk of postoperative atrial fibrillation (POAF) (RR 0.70 [95% CI 0.59-0.83], p < 0.001). However, between the groups, there was no statistically significant difference in the risk of all-cause mortality (ACM) (RR 0.81 [95% CI 0.39-1.69], p = 0.57, I
conclusionThis meta-analysis demonstrates that colchicine appears to reduce the risk of POAF. However, it does not significantly affect the risks in terms of PPM, ACM, or stroke. REGISTRATION: PROSPERO identifier no. CRD420251117966.
Identifiers
42999009What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.