Evidence map›Paper›PMID 42991192›Full record

ReviewBiologics : targets & therapy2026

TRPM7 as a Magnesium-Sensing Metabolic Checkpoint in Pancreatic β-Cell Failure and Type 2 Diabetes: From Mechanistic Insights to a Functional Biomarker Strategy.

Marie Gorette Kampire, Jean Claude Hakizimana, Joseph Mucumbitsi, Callixta Kaneza, Bushobozi Themistocles, Sophie Mukantwari, Jean Mfizi Ngaboyishema, Alex Mathias Buteera, Abdullateef Isiaka Alagbonsi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biologics : targets & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marie Gorette Kampire *Department of Biochemistry, Adventist University of Central Africa (AUCA); Adventist School of Medicine of East Central Africa (ASOME), Kigali, Rwanda.
Jean Claude Hakizimana *Department of Physiology, School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Huye, Rwanda.ORCID 0009-0002-4749-1540
Joseph Mucumbitsi *Department of Microbiology, Adventist University of Central Africa (AUCA); Adventist School of Medicine of East Central Africa (ASOME), Kigali, Rwanda.
Callixta Kaneza *Department of Microbiology, Adventist University of Central Africa (AUCA); Adventist School of Medicine of East Central Africa (ASOME), Kigali, Rwanda.
Bushobozi Themistocles *Department of Microbiology, Adventist University of Central Africa (AUCA); Adventist School of Medicine of East Central Africa (ASOME), Kigali, Rwanda.
Sophie Mukantwari *Department of Intensive Care Unit, Centre Hospitalier Universitaire de Kigali / University Teaching Hospital of Kigali (CHUK), Kigali, Rwanda.
Jean Mfizi NgaboyishemaVice Dean, Adventist School of Medicine of East-Central Africa (ASOME), Kigali, Rwanda.
Alex Mathias ButeeraAssociate Dean of Medical Education, Adventist School of Medicine of East-Central Africa (ASOME), Kigali, Rwanda.
Abdullateef Isiaka AlagbonsiDepartment of Physiology, School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Huye, Rwanda.ORCID 0000-0002-5462-9950

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Traditional clinical chemistry views magnesium (Mg Methods: Following the PRISMA 2020 guideline, a systematic search was conducted in PubMed, Scopus, and Web of Science (inception to May 2026). Only original peer-reviewed studies examining TRPM7 in β-cell function, insulin secretion/synthesis, or compensatory proliferation in obesity/T2D contexts were included. Results: Five original studies met the strict criteria. One key study demonstrated that β-cell-specific TRPM7 kinase inactivation impairs insulin synthesis and compensatory β-cell proliferation via AKT/ERK signaling, leading to glucose intolerance in obesity despite normal serum Mg Conclusion: TRPM7 may represent a Mg

Indexed as

insulin secretionmagnesium signalingpancreatic β-cellsTRPM7type 2 diabetes

Identifiers

PMID42991192
PMCPMC13735400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.