ArticleHealth science reports2026
Association of Vascular Endothelial Growth Factor A +936 C/T Polymorphism With Non-Alcoholic Fatty Liver Disease in a Bangladeshi Population: A Case-Control Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: Non-Alcoholic Fatty Liver Disease (NAFLD) ranges from hepatic steatosis to advanced cirrhosis. Polymorphisms in the vascular endothelial growth factor A (VEGFA) gene can change its expression, potentially altering angiogenesis and advancing disease stage. This study aimed to evaluate the association between the VEGFA +936 C/T polymorphism and susceptibility to NAFLD in a Bangladeshi population. Methods: A case-control study was conducted including 100 NAFLD patients and 100 controls. NAFLD was diagnosed by ultrasonography. Genotyping was performed using allele-specific polymerase chain reaction followed by gel electrophoresis. Biochemical parameters were measured using standard enzymatic methods following the manufacturer's instructions. Results: The frequency of the T allele was significantly higher in NAFLD patients compared to controls (22.5% vs. 12%). The control genotype distribution was consistent with Hardy-Weinberg equilibrium ( Conclusion: This study demonstrated a significant association between the VEGFA +936 C/T polymorphism and susceptibility to NAFLD in a Bangladeshi population. However, due to the small sample size and limited number of TT individuals, further large-scale and functional studies are required to validate these findings.
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