Evidence map›Paper›PMID 42986298›Full record

ArticleGut microbes2026

Lactylated MOESIN links gut metabolism to TGF-β-driven immune remodeling and bone protection in diabetic osteoporosis.

Jiajia Lu, Xinyu Wang, Sheng Zhou, Jianlin Zhang, Qiang Fu, Lianbo Xiao, Nan Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiajia LuDepartment of Orthopedic Trauma, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.ORCID 0000-0003-0957-592X
Xinyu WangDepartment of Orthopedic, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
Sheng ZhouDepartment of Orthopedic Surgery, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu, P. R. China.
Jianlin ZhangBaoji Traditional Chinese Medicine Hospital, Baoji, Shanxi, P. R. China.
Qiang FuDepartment of Orthopedic Trauma, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.
Lianbo XiaoDepartment of Orthopedic, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
Nan LuDepartment of Orthopedic Trauma, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic osteoporosis is characterized by impaired bone homeostasis and immune dysregulation. We investigated how fecal microbiota transplantation (FMT) modulates microbial metabolism, immune signaling, and bone remodeling using a pilot clinical cohort and diabetic mouse models. The clinical component was treated as a safety/feasibility study with exploratory longitudinal BMD and serum biomarker endpoints. In experimental DOP models, FMT improved bone microarchitecture and reduced inflammatory and bone-resorption markers. Descriptive analysis of external PBMC scRNA-seq data (GSE274561) provided immune-cell context, while an independently replicated external splenic CD4

Indexed as

Bone RemodelingMicrofilament ProteinsOsteoporosisTransforming Growth Factor betaAnimalsDisease Models, AnimalFecal Microbiota TransplantationFemaleHumansMaleMiceSignal TransductionTh17 CellsT-Lymphocytes, RegulatoryMicrofilament ProteinsmoesinTransforming Growth Factor betadiabetic osteoporosisFecal microbiota transplantationlactate metabolismlactylated MOESINRegulatory T Cell/T Helper 17 BalanceTGF-β signaling pathway

Identifiers

PMID42986298
PMCPMC13757687

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.