Evidence map›Paper›PMID 42985244›Full record

ArticleMaterials today. Bio2026

Triaptosis-based biomimetic nanoparticle for the treatment of oral squamous cell carcinoma lymph node metastasis.

Zi-Zhan Li, Jinmei Wu, Kan Zhou, Ziyan Yuan, Han-Yue Luo, Yi Liu, Lei-Ming Cao, Guang-Rui Wang, Bing Liu, Qiuji Wu and 3 more

Abstract read
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In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zi-Zhan LiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, Department of Oral & Maxillofacial - Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
Jinmei WuNational Key Laboratory of Agricultural Microbiology, College of Chemistry, Huazhong Agricultural University, Wuhan, 430070, China.
Kan ZhouState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, Department of Oral & Maxillofacial - Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
Ziyan YuanNational Key Laboratory of Agricultural Microbiology, College of Chemistry, Huazhong Agricultural University, Wuhan, 430070, China.
Han-Yue LuoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, Department of Oral & Maxillofacial - Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
Yi LiuKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.
Lei-Ming CaoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, Department of Oral & Maxillofacial - Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
Guang-Rui WangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, Department of Oral & Maxillofacial - Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
Bing LiuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, Department of Oral & Maxillofacial - Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
Qiuji WuDepartment of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Chun XuSydney Dental School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2006, Australia.
Zhiyong SongNational Key Laboratory of Agricultural Microbiology, College of Chemistry, Huazhong Agricultural University, Wuhan, 430070, China.
Lin-Lin BuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, Department of Oral & Maxillofacial - Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymph node metastasis (LNM) is a major determinant of poor prognosis in oral squamous cell carcinoma (OSCC) and remains difficult to treat due to the immunosuppressive tumor microenvironment and limited response to immune checkpoint blockade. Here, we report a biomimetic nanotherapeutic platform designed to induce triaptosis and enhance antitumor immunity for the treatment of metastatic OSCC. Semaglutide-loaded cerium oxide nanoparticles were engineered and further coated with macrophage membranes to construct Semg@Ce@MM, enabling improved tumor targeting and immune compatibility. The nanoplatform exerts dual therapeutic actions: cerium-mediated pro-oxidative activity triggers VPS34-associated triaptosis characterized by cytoplasmic vacuolization, while semaglutide activates MAPK signaling to enhance tumor cell susceptibility to death.

Indexed as

Cancer immunotherapyCerium oxide nanoparticlesLymph node metastasisNanoparticlesTriaptosis

Identifiers

PMID42985244
PMCPMC13733471

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.