ArticleTherapeutic advances in medical oncology2026
Clinicopathologic and molecular features of head and neck NUT carcinoma: Analysis of 25 cases, including 5 with adenoid differentiation.
Article in Therapeutic advances in medical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Nuclear protein in testis (NUT) carcinoma is a highly aggressive malignancy driven by Objective: To characterize the pathological and molecular features of primary head and neck NUT carcinoma and explore optimal management strategies. Design: This study was a single-center retrospective analysis. Methods: Fluorescence in situ hybridization was used to detect Results: This study included 25 patients with NUT carcinoma. Adenoid differentiation was observed in 5 cases (2 Conclusion: Patients with NUT with adenoid differentiation or different gene fusions exhibit distinct gene expression profiles and immune landscapes. Neuroendocrine differentiation is associated with poor prognosis. Radiotherapy may be associated with favourable outcomes and warrants further investigation.
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