ArticleReviews in cardiovascular medicine2026
Moderate-Dose Exercise Protects Against Heart Failure via Apelin/NLRP3 Mediated Inflammation.
Article in Reviews in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Background: Heart failure (HF) remains a major cause of cardiovascular mortality worldwide, imposing a substantial burden on healthcare systems. Although physical exercise is known to exert cardioprotective effects, its underlying mechanisms are not fully understood. Methods: We established a post-myocardial infarction (MI) HF mouse model via coronary artery ligation, followed by an 8-week exercise regimen at different intensities. Multi-omics sequencing was performed to identify alterations in inflammatory and metabolic pathways. Results: Moderate-dose exercise preserved cardiac function and attenuated ventricular remodeling. Metabolomic analysis indicated modulation of lipid metabolism and inflammation via the Apelin pathway. Transcriptomics revealed that the nucleotide-binding oligomerization domain (NOD)-like receptor signaling pathway, which was elevated after MI, was suppressed by moderate-dose exercise. Additionally, Nuclear factor erythroid 2-related factor 2 (Nrf2)-a key transcription factor regulating antioxidant and anti-inflammatory responses-was upregulated in the moderate-exercise group. Conclusions: Moderate-dose exercise protects against HF in mice by regulating lipid metabolism and inflammatory pathways. These findings support the standardization of exercise therapy for secondary prevention of cardiovascular disease.
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