Evidence map›Paper›PMID 42982931›Full record

ArticleSleep & breathing = Schlaf & Atmung2026

The growing burden of coexisting sleep apnea and acute myocardial infarction among adults aged 55 years and older in the United States, 2006-2023.

Rawdah Shakil, Muhammad Salman Nadeem, Hamza Shakil, Sameer Ehtesham, Ammad Uddin, Haris Mahmood, Saqlain Anwar, Huzaifa Sabir Nawaz, Sohaib Aftab Ahmed Chaudhry, Adeena Jamil

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Article in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Rawdah ShakilDepartment of Medicine, Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Muhammad Salman NadeemDepartment of Medicine, Nishtar Medical University, Multan, Pakistan.
Hamza ShakilDepartment of Medicine, Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Sameer EhteshamDepartment of Medicine, Ziauddin University, Karachi, Pakistan.
Ammad UddinDepartment of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Haris MahmoodDepartment of Medicine, Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Saqlain AnwarPNS Shifa Hospital, Karachi, Pakistan. Saqlainanwar667@gmail.com.ORCID http://orcid.org/0009-0006-9707-9588
Huzaifa Sabir NawazServices Institute of Medical Sciences, Lahore, Pakistan.
Sohaib Aftab Ahmed ChaudhryDepartment of Medicine, ABWA Medical College, Faisalabad, Pakistan.
Adeena JamilDepartment of Medicine, Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSleep apnea (SA) is a highly prevalent condition in the United States and increases mortality risk in patients with acute myocardial infarction (AMI). We examined demographic and geographic national trends in mortality involving both SA and AMI from 2006 to 2023.

methodThis cross-sectional, population-based study used death certificates from the CDC WONDER database (2006-2023) mentioning both SA and AMI to assess mortality involving both conditions among adults aged ≥ 55 years using ICD-10 codes I21-I22 (AMI) and G47.3 (SA). Age-adjusted mortality rates (AAMRs) per million with 95% CIs were analyzed, and annual percentage changes (APCs) were calculated using Joinpoint regression across demographic and geographic subgroups.

resultFrom 2006 to 2023, 18,388 deaths involving both SA and AMI occurred. While AMI-related mortality declined over time, mortality involving both SA and AMI increased. AAMRs involving both SA and AMI rose from 2006 to 2018 (APC: 5.07; 95% CI: 4.54 to 5.50), showed a steeper increase from 2018 to 2021 (APC: 13.71; 95% CI: 11.30 to 15.29), then declined by 2023 (APC:-6.46; 95% CI: -8.98 to -3.99). AAMRs among men were nearly three times those of women. Non-Hispanic (NH) Whites and NH Blacks had the highest AAMRs, while Hispanics had the lowest. The Midwest had the highest regional AAMR and the Northeast the lowest, while South Dakota and Nevada had the highest and lowest state-level AAMRs, respectively. From 2006 to 2020, rural areas showed higher AAMRs than urban areas.

conclusionWhile AMI-related mortality declined, mortality involving both SA and AMI increased from 2006 to 2021, with a decline from 2021 to 2023. Disparities persisted in men, NH Whites and NH Blacks, and those in the Midwest and rural areas. Whether targeted strategies, such as rigorous SA screening and prompt treatment, can reduce this growing burden warrants further study.

Indexed as

Myocardial InfarctionSleep Apnea SyndromesAgedAged, 80 and overComorbidityCross-Sectional StudiesFemaleHumansMaleMiddle AgedUnited StatesAcute myocardial infarctionCDC WONDERHealth disparitiesMortality trendsSleep apnea

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.