ReviewTouchREVIEWS in endocrinology2026
Disease-modifying approach to cardiovascular-kidney-metabolic syndrome: The role of combining GLP-1RAs and SGLT-2is.
Review in TouchREVIEWS in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular-kidney-metabolic (CKM) syndrome represents a recent paradigm shift from a traditional, fragmented, disease-specific approach to an interconnected, holistic one driven by shared pathophysiologic pathways that are crucial to the development of multisystem organ dysfunction. The escalating global prevalence of CKM syndrome, associated with industrialization, the obesity pandemic and aging demographics, necessitates a fundamental reframing toward the simultaneous and coordinated management of cardiac, renal and metabolic health. Core to this integrated approach is the development of novel therapeutic options, such as glucagon-like peptide-1 receptor agonists (GLP-1 RA) and sodium-glucose cotransporter-2 inhibitors (SGLT-2i), which target these common mechanisms and have the potential to improve long-term prognosis and reverse trends in cardiovascular mortality. In this article, we suggest a strategic roadmap for CKM syndrome to prioritize early, interdisciplinary intervention focused on addressing modifiable risk factors, weight management and tailored treatment protocols, particularly for high-risk populations, to mitigate the detrimental impact of this multiorgan condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.