Evidence map›Paper›PMID 42979377›Full record

ArticleEuropean heart journal open2026

Acute and 6-month vascular effects of a multi-component nutritional supplement: a randomized controlled trial.

Charles Piercy, Jenny Harris, Kenza Sackho, Paola Campagnolo, Diogo Barardo, Ben Creagh-Brown, Christian Heiss

Registry-linked trialAbstract read
In one paragraph

Article in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06145087 (Investigation of Short and Intermediate Term Effects of a Supplement Mix Designed to Target Ageing Mechanisms on Vascular Function in Healthy Middle-aged Participants), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06145087 nacompletednot on this map

Investigation of Short and Intermediate Term Effects of a Supplement Mix Designed to Target Ageing Mechanisms on Vascular Function in Healthy Middle-aged Participants (STAMINA Study)

TypeinterventionalSponsorUniversity of SurreyRan2023 to 2025Enrolled61ConditionsHealthy Aging, Vascular DilationArms"NOVOS Core" supplement, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Charles PiercyFaculty of Health and Medical Sciences, University of Surrey, Kate Granger Building, 30 Priestley Road, Guildford GU2 7YJ, UK.ORCID https://orcid.org/0000-0003-2942-7617
Jenny HarrisFaculty of Health and Medical Sciences, University of Surrey, Kate Granger Building, 30 Priestley Road, Guildford GU2 7YJ, UK.ORCID https://orcid.org/0000-0001-8933-117X
Kenza SackhoFaculty of Health and Medical Sciences, University of Surrey, Kate Granger Building, 30 Priestley Road, Guildford GU2 7YJ, UK.
Paola CampagnoloFaculty of Health and Medical Sciences, University of Surrey, Kate Granger Building, 30 Priestley Road, Guildford GU2 7YJ, UK.ORCID https://orcid.org/0000-0002-8957-3969
Diogo BarardoNOVOS Labs, 100 Park Avenue 16th Floor, New York, NY 10017, USA.ORCID https://orcid.org/0000-0001-6177-0728
Ben Creagh-BrownFaculty of Health and Medical Sciences, University of Surrey, Kate Granger Building, 30 Priestley Road, Guildford GU2 7YJ, UK.ORCID https://orcid.org/0000-0002-4397-1232
Christian HeissFaculty of Health and Medical Sciences, University of Surrey, Kate Granger Building, 30 Priestley Road, Guildford GU2 7YJ, UK.ORCID https://orcid.org/0000-0002-3212-8995

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: To evaluate 6-month effects of a multi-ingredient nutritional powder formulation targeting complementary pathways relevant to vascular ageing on endothelial function and other vascular ageing markers in apparently healthy adults. Methods and results: The Conclusion: Daily intake of a multi-ingredient nutritional powder formulation was associated with sustained improvements in endothelial function, arterial stiffness, and systolic blood pressure, with a modest reduction in estimated 10-year cardiovascular risk primarily attributable to lower systolic blood pressure rather than lipid change. Registration: clinicaltrials.gov NCT06145087.

Indexed as

Blood pressureDietary supplementsFlow-mediated dilationPulse wave velocityVascular ageing

Identifiers

PMID42979377
PMCPMC13730552

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.