ReviewActa pharmaceutica Sinica. B2026
Spatiotemporal crosstalk of post-translational modifications: A therapeutic avenue in spinal cord injury.
Review in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal cord injury (SCI) triggers irreversible neurological dysfunction driven by sequential primary and secondary insults, with neuronal death and neuroinflammation as the central pathological determinants. Despite advances in neuroregeneration research, an incomplete understanding of the molecular regulators underlying these processes limits the development of effective SCI treatment strategies. Post-translational modifications (PTMs) function as critical "dynamic molecular switches" that spatiotemporally regulate protein function and signaling cascades, shaping the SCI microenvironment. Emerging evidence suggests that interdependent PTM networks-rather than isolated modifications-regulate the balance between deterioration and repair. This review synthesizes current insights into seven major PTMs implicated in neuronal death and neuroinflammation after SCI, emphasizing their cooperative crosstalk and the methodological challenges in decoding their temporal dynamics. We propose a "spatiotemporally regulated PTM network" framework to guide therapeutic interventions, highlighting multiplex PTM modulation as a promising strategy to enhance neuronal survival, reduce neuroinflammation, and promote functional recovery after SCI. This review deepens the understanding of PTM crosstalk in SCI pathology and provides new perspectives for developing novel PTM detection and clinical therapeutic strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.