ReviewNature reviews. Rheumatology2026
Circadian rhythms in arthritis: from pathophysiology to chronotherapy.
Review in Nature reviews. Rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arthritis is characterized by pain and inflammation of the joints, with the most common forms being osteoarthritis (OA) and rheumatoid arthritis (RA). These conditions affect a sizeable portion of the adult population, creating substantial health and socioeconomic burdens. Dysregulated inflammatory pathways contribute to arthritis and represent important targets for current and emerging therapies. Symptoms and cytokine levels change dynamically over time in arthritis, varying not only with disease state (such as flare-ups) but also with daily circadian rhythms. Daily fluctuations in rheumatoid arthritis symptoms are well established and parallel changes in inflammatory mediators, whereas osteoarthritis seems to exhibit more variable and patient-specific temporal patterns. Current treatments generally do not account for these biological rhythms. However, growing evidence suggests that aligning therapy with circadian fluctuations (termed 'chronotherapy') could improve outcomes and reduce adverse effects, although practical implementation remains challenging. Emerging synthetic biology approaches aim to enable timed drug delivery by harnessing the endogenous genetic mechanisms that regulate cellular rhythms. Together, these advances highlight opportunities for translating circadian-based therapies into clinical practice.
Identifiers
42977800What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.