SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Effectiveness of home-based exercise interventions on cardiorespiratory fitness and cancer treatment-related cardiovascular toxicity in cancer survivors exposed to cardiotoxic therapies: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the effectiveness of home-based exercise (HBE) interventions on cardiorespiratory fitness and cancer treatment-related cardiovascular toxicity (CTR-CVT) in cancer survivors.
methodsA comprehensive search of seven electronic databases was conducted for randomized controlled trials (RCTs) published from January 2000 to October 2025. The participants were cancer survivors who had received cardiotoxic therapies. The interventions were structured HBE programmes. Eligible studies were those that reported on any outcomes related to CTR-CVT. The primary outcomes included direct cardiotoxicity parameters (e.g., left ventricular ejection fraction [LVEF] and global longitudinal strain [GLS]) and cardiac biomarkers (e.g., troponins and B-type natriuretic peptide); clinical cardiovascular events (e.g., heart failure and arrhythmias); cardiorespiratory fitness (e.g., peak oxygen uptake [VO
resultsTen RCTs involving 851 participants were included. The meta-analysis demonstrated that the HBE interventions significantly improved VO
conclusionWhile HBE improved cardiorespiratory fitness (VO CLINICAL TRIAL NUMBER: not applicable.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.