ArticleFrontiers in nutrition2026
Nonlinear association of cholesterol, high-density lipoprotein, and glucose index with the risk of prediabetes and diabetes in normal-weight middle-aged and older Chinese adults: a multicenter retrospective cohort study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The relationship between the cholesterol, high-density lipoprotein, and glucose (CHG) index and dysglycemia is widely recognized in the general population; however, this relationship has been much less examined among normal-weight, middle-aged and older adults-a subgroup routinely marginalized in metabolic research. Accordingly, the current study was designed to evaluate the relationship of the CHG index with incident prediabetes and diabetes specifically among this population. Methods: The study cohort comprised 19,981 Chinese adults (age ≥45 years, BMI 18.5-23.9 kg/m Results: During an average follow-up of 3.19 years, a higher CHG index was significantly linked to a greater risk of the outcome. After adjustment (Model 3), the hazard ratio (HR) for the CHG index as a continuous variable was 2.20 (95% CI: 1.90-2.54). Compared with Quartile 1, the HRs for Quartiles 2, 3, and 4 were 1.42, 1.86, and 1.91, respectively (all Conclusion: This study indicates a nonlinear positive association between the CHG index and the risk of incident prediabetes and diabetes among normal-weight middle-aged and older Chinese adults. Future research employing large prospective cohorts is warranted to fully explicate the mechanisms and establish a causal nexus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.