ArticleCureus2026
Serum Lipid Abnormalities and Age-Related Cataract: A Hospital-Based Case-Control Study in North India.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDyslipidaemia may contribute to age-related cataract through altered lens membrane homeostasis, oxidative stress and lipid peroxidation, but clinical evidence remains inconsistent.
objectiveTo compare serum lipid profiles in adults with and without age-related cataract and quantify the independent associations of specific lipid abnormalities with cataract.
methodsThis hospital-based case-control study included 300 adults aged 50 years or older at a tertiary care centre in Kanpur, India, from April 2024 to October 2025. Cases were 150 patients with age-related cataract, and controls were 150 participants without cataract. Patients with diabetes, secondary cataract or lipid-lowering therapy were excluded. Fasting total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein cholesterol (VLDL-C) and high-density lipoprotein cholesterol (HDL-C) were measured by enzymatic colourimetry. Separate multivariable logistic regression models adjusted each lipid abnormality for age, sex, education, occupation, smoking, alcohol use and socioeconomic status.
resultsCases were older than controls (63.07 ± 6.14 vs 60.70 ± 6.67 years; p = 0.002). Compared with controls, cases had higher total cholesterol (209.62 ± 33.23 vs 183.10 ± 28.08 mg/dL), triglycerides (169.42 ± 34.47 vs 146.65 ± 27.12 mg/dL), LDL-C (138.69 ± 30.45 vs 119.17 ± 21.27 mg/dL) and VLDL-C (33.89 ± 6.89 vs 29.33 ± 5.42 mg/dL), and lower HDL-C (39.49 ± 5.90 vs 45.95 ± 6.75 mg/dL; all p < 0.001). Adjusted odds of cataract were higher with low HDL-C (adjusted odds ratio {aOR} 3.91, 95% confidence interval {CI} 2.22-6.89), high LDL-C (aOR 3.06, 95% CI 1.86-5.04), high VLDL-C (aOR 3.03, 95% CI 1.84-5.00), high triglycerides (aOR 2.69, 95% CI 1.64-4.43) and high total cholesterol (aOR 2.49, 95% CI 1.54-4.05). Lipid distributions did not differ significantly across the 15 recorded cataract morphology categories.
conclusionDyslipidaemia, particularly low HDL-C and elevated atherogenic lipids, was independently associated with age-related cataract in this hospital population. These findings identify a clinically relevant metabolic correlate but do not establish causality. Prospective population-based studies should determine whether lipid abnormalities predict cataract onset or progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.