ArticleJournal of oral microbiology2026
Alterations in oral microbiome and salivary metabolome profiles associated with myocardial infarction: a case-control study.
Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Few studies have comprehensively profiled both the salivary microbiome and metabolome in myocardial infarction (MI). This case-control study therefore characterized microbial and metabolic alterations in MI patients and identified potential diagnostic signatures. Methods: Seventy participants (35 MI patients and 35 matched healthy controls) were enrolled. Salivary microbiota were profiled via 16S rRNA (V3-V4) sequencing, and metabolites were analyzed using untargeted LC-MS. Microbial diversity, taxonomic composition, and predicted functional pathways were assessed. Diagnostic performance was evaluated by ROC analysis, and microbiota-metabolite correlations. Results: Significant differences in oral microbial diversity were observed between MI patients and controls. MI patients exhibited significantly higher alpha diversity and a distinct community structure, with beta diversity separating between groups. Enriched taxa included Conclusion: MI is associated with distinct oral microbial and salivary metabolomic signatures. A four-metabolite panel shows promise as a potential non-invasive biomarker signature, though external validation is required. Given the cross-sectional design, causality cannot be established.
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