Evidence map›Paper›PMID 42963350›Full record

ArticleNPJ digital medicine2026

Implementation strategies for digital relapse prevention in schizophrenia identified during a randomized controlled trial.

Selina Hiller, Katharina Prietzel, Mohamed Shehata, Soňa Nevická Sikorová, Eduard Bakstein, Kateřina Urbanová, Graziella Leone, Laura Emde, Denise Jais, Theodor Lorenzen and 5 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Selina HillerTechnical University of Munich, School of Medicine and Health, Department of Psychiatry and Psychotherapy, TUM University Hospital, Munich, Germany. selina.hiller@tum.de.ORCID http://orcid.org/0000-0003-0041-7722
Katharina PrietzelTechnical University of Munich, School of Medicine and Health, Department of Psychiatry and Psychotherapy, TUM University Hospital, Munich, Germany.
Mohamed ShehataTechnical University of Munich, School of Medicine and Health, Department of Psychiatry and Psychotherapy, TUM University Hospital, Munich, Germany.
Soňa Nevická SikorováMindpax.me, Prague, Czech Republic.
Eduard BaksteinMindpax.me, Prague, Czech Republic.
Kateřina UrbanováMindpax.me, Prague, Czech Republic.
Graziella Leonekbo-Isar-Amper-Klinikum Region München, München-Haar, Germany.
Laura EmdeCharité - Universitätsmedizin Berlin, Department of Psychiatry and Neuroscience, Campus Benjamin Franklin, Berlin, Germany.
Denise JaisCharité - Universitätsmedizin Berlin, Department of Psychiatry and Neuroscience, Campus Benjamin Franklin, Berlin, Germany.
Theodor LorenzenCharité - Universitätsmedizin Berlin, Department of Psychiatry and Neuroscience, Campus Benjamin Franklin, Berlin, Germany.
Samuel TrummCharité - Universitätsmedizin Berlin, Department of Psychiatry and Neuroscience, Campus Benjamin Franklin, Berlin, Germany.
Marco ZierhutCharité - Universitätsmedizin Berlin, Department of Psychiatry and Neuroscience, Campus Benjamin Franklin, Berlin, Germany.ORCID https://orcid.org/0000-0003-3109-9050
Wolfgang StrubeDepartment of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Stefan LeuchtTechnical University of Munich, School of Medicine and Health, Department of Psychiatry and Psychotherapy, TUM University Hospital, Munich, Germany.ORCID https://orcid.org/0000-0002-4934-4352
Kerem BögeDZPG (German Center for Mental Health), Partner Site Berlin, Berlin, Germany.

Funding

Innovation Fund of the Federal Government Germany 01VSF22033
6 · The paper itself

Abstract

Digital mental health technologies hold promise, yet their integration into routine care remains challenging. This study reports findings from an implementation workshop conducted midway through an ongoing multi-site randomized controlled trial (RCT) evaluating a smartphone-based relapse prevention app for patients with schizophrenia and schizoaffective disorder. Sixteen stakeholders, including developers, researchers, and clinicians, discussed experiences and barriers using a semi-structured agenda, incorporating prior feedback from three focus groups with people with lived experience, and analyzed the discussions using an adopted R(E)-AIM framework (Reach, Adoption, Implementation, and Maintenance). Findings highlight the need for structural, technical, and personnel adjustments to support sustainable implementation. Key recommendations include integrating digital tools into discharge planning, enhancing interdisciplinary collaboration, delegating digital responsibilities, and streamlining technical workflows to facilitate seamless adoption. These insights inform feasibility considerations and strategic requirements for digital interventions in severe mental illness, offering guidance for future RCTs and practice-oriented integration of digital therapeutics in psychiatric care.

Identifiers

PMID42963350
PMCPMC13722681

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.