A tandem repeat in TCF25 intron 1 is associated with MC1R activation through dual mechanisms of transcriptional derepression and chromatin looping underlying black plumage in chickens.

Xueying Wu, Li Rong, Tong Yu, Yuting Zhou, Jiao Li, Shijun Li

Abstract read

In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Xueying WuKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology and College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.

Li RongKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology and College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.

Tong YuKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology and College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.

Yuting ZhouKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology and College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.

Jiao LiYazhouwan National Laboratory, Sanya, 572024, PR China; Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology and College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.

Shijun LiCollege of Animal Science & Technology, Hainan Research Institute Huazhong Agricultural University, Wuhan, Hubei Province, 430070, China; Yazhouwan National Laboratory, Sanya, 572024, PR China; Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology and College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Hubei Hongshan Laboratory, Wuhan, Hubei Province, 430070, China. Electronic address: lishijun@mail.hzau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plumage pigmentation in chickens offers important insights into the genetic basis of phenotypic diversification. Although melanocortin-1 receptor gene (MC1R) is a central regulator of melanogenesis, the regulatory mechanisms contributing to extended black plumage remain incompletely understood. In this study, we integrated genome-wide association analysis (GWAS) in an F₂ resource population with multi-breed validation (n = 153) cohorts to identify a significant locus on chromosome 11 encompassing MC1R (top SNP P = 1.95 × 10⁻

Indexed as

Black plumage pigmentationChromatin regulationGenetic adaptationMelanocortin-1 receptorTandem duplication

Identifiers

PMID42962490

DOI10.1016/j.psj.2026.107987

PMCPMC13743518

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.