ArticleAsian biomedicine : research, reviews and news2026
Correlations between serum acute-phase protein SAA, platelet-to-lymphocyte ratio, and disease activity in ankylosing spondylitis.
Article in Asian biomedicine : research, reviews and news, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease characterized by sacroiliitis and spinal osteophyte formation that needs sophisticated testing to improve the accuracy of activity assessment and clinical decision-making. Objective: To investigate the clinical value of serum amyloid A (SAA) and platelet-to-lymphocyte ratio (PLR) in assessing disease activity in patients with AS. Methods: Using the bath ankylosing spondylitis disease activity index (BASDAI), 160 AS patients were categorized into 3 subgroups: low activity (BASDAI <4, n = 60), moderate activity (4≤ BASDAI <6, n = 50), and high activity (BASDAI ≥6, n = 50). Quantitative measurements included SAA concentrations and PLR values, with subsequent analysis of their relationship to disease progression. Diagnostic performance was evaluated with receiver operating characteristic (ROC) curve methodology. Results: The high-activity group showed significantly elevated SAA (48.3 mg/L ± 9.1 mg/L) and PLR (164.5 ± 29.2) versus moderate- (SAA: 29.0 mg/L ± 8.2 mg/L; PLR: 138.4 ± 27.6) and low-activity groups (SAA: 14.3 [11.7-17.2] mg/L; PLR: 102.7 ± 22.2) (all Conclusion: SAA and PLR are strongly associated with BASDAI-defined disease activity in AS, and combined assessment improves identification of high disease activity, supporting their potential role as objective adjunctive markers in clinical assessment.
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