ArticleFrontiers in nutrition2026
Uric acid-to-HDL-cholesterol ratio and incident carotid atherosclerosis: a retrospective cohort study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The uric acid-to-HDL-cholesterol ratio (UHR) has been proposed as a composite cardiometabolic biomarker, but prospective evidence linking UHR to incident carotid atherosclerosis remains limited. Methods: In a retrospective cohort of 16,572 adults from a tertiary health examination center in Zhejiang, China, we examined the association between baseline UHR and incident carotid artery lesions using Cox proportional hazards regression. Incremental predictive performance was evaluated using C-statistic, integrated discrimination improvement, continuous net reclassification improvement, median improvement in individual predicted event probabilities, and decision curve analysis. Results: Over a mean follow-up of 2.7 years, 4,454 incident events occurred. Each 1-SD increment in baseline UHR was independently associated with a 6% higher hazard of incident carotid artery lesions (HR 1.06, 95% CI 1.01-1.11; Conclusion: Higher baseline UHR was independently associated with short-term carotid atherosclerotic progression. Exploratory analyses suggested a possible sex difference, but this requires confirmation in adequately powered studies. While UHR provides independent prognostic information, it does not meaningfully improve risk stratification beyond traditional cardiovascular risk factors in health examination populations.
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