ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2026
Targeting cGMP pathways: the impact of vericiguat and high intensity interval training on mammary cancer progression in female mice.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND &
objectivesRecent studies confirmed the involvement of the cGMP pathway in regulating tumorigenesis. This research assessed the effect of high-intensity interval training (HIIT) and Vericiguat on the cGMP pathway in a BALB/c mouse model of mammary cancer.
methodsSeventy BALB/C female mice were randomly divided into seven groups: Healthy Control (CON), PBS, Cancer (CA), Cancer+Exercise (CA + EX), Cancer+Vericiguat (CA + VER), Cancer+Vehicle (CA + V), and Cancer+Exercise+Vericiguat (CA + EX+VER). The cancer groups received injections of 4T1 cells to induce mammary tumors. Following tumor induction, the exercise groups performed 6 weeks of HIIT, which consisted of running at 80-95% of Vmax, 4-10 intervals, and five sessions per week, and drug groups received 0.5 mg/kg Vericiguat. RESULTS &
conclusionThe protein expression of sGC, PKG, cGMP, and BAX in breast tumor tissue was lower, while Bcl2, Cyclin D1, and Survivin were higher in CA compared with CON. However, EX, VER, and their combination increased the expression of sGC, PKG, cGMP, and BAX, and decreased the expression of Cyclin D1, Bcl2, and Survivin. Tumor volume decreased in all treated groups compared to the CA group in weeks 3-8. These findings suggest that the combination of EX and VER may be a promising therapeutic strategy for mammary cancer treatment by modulating cGMP signaling.
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