Evidence map›Paper›PMID 42951841›Full record

ArticleHippocampus2026

Hippocampal Subfield Volumes and Spatial Memory Performance in Older Adults At-Risk for Type 2 Diabetes.

Jennifer Hanna Al-Shaikh, Olivia R Ghosh-Swaby, Ali R Khan, Jane Thornton, Timothy J Bussey, Lisa M Saksida, Daniel Palmer, Teresa Liu-Ambrose, Lindsay S Nagamatsu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hippocampus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jennifer Hanna Al-ShaikhGraduate Program in Neuroscience, Western University, London, Ontario, Canada.ORCID https://orcid.org/0009-0009-2819-0655
Olivia R Ghosh-SwabyGraduate Program in Neuroscience, Western University, London, Ontario, Canada.
Ali R KhanRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-0760-8647
Jane ThorntonDepartment of Epidemiology & Biostatistics, Western University, London, Ontario, Canada.
Timothy J BusseyRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Lisa M SaksidaRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Daniel PalmerRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-3419-8647
Teresa Liu-AmbroseDepartment of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0003-1016-196X
Lindsay S NagamatsuSchool of Kinesiology, Western University, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-5444-8965

Funding

Canada First Research Excellence FundCIHRNatural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2016-05052
6 · The paper itself

Abstract

Older adults at risk for type 2 diabetes (T2D) are more likely to experience accelerated cognitive aging and neurodegeneration due to impaired metabolism in the hippocampus. However, the precise relationship between T2D risk factors, brain volumes (i.e., gray matter, white matter, hippocampus subfields), and hippocampus-dependent functions (i.e., spatial pattern separation, a component of spatial memory) remains unexplored. To investigate these relationships in this cross-sectional study, 60 older adults at risk for T2D (e.g., high BMI or elevated A1c levels) completed a touchscreen-based spatial pattern separation behavioral task-the Trial-Unique delayed Nonmatching-to-Location (TUNL) and magnetic resonance imaging (MRI). HippUnfold was utilized to segment the hippocampus from high-resolution, T

Indexed as

Diabetes Mellitus, Type 2HippocampusSpatial MemoryAgedAgingCross-Sectional StudiesFemaleGlycated HemoglobinHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsOrgan SizeGlycated HemoglobinHippocampal subfield volumesmagnetic resonance imagingregional brain volumetouchscreen trial‐unique delayed non‐matching to locationtype 2 diabetes risk

Identifiers

PMID42951841
PMCPMC13716845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.