Evidence map›Paper›PMID 42950002›Full record

SynthesiseLife2026

Ultrasound neuromodulation hypotheses on the directionality of effects and community resource.

Hugo Caffaratti, Ben Slater, Nour Shaheen, Ariane E Rhone, Ryan Calmus, Michael Kritikos, Sukhbinder Kumar, Brian Dlouhy, Hiroyuki Oya, Timothy D Griffiths and 8 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Hugo CaffarattiDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.ORCID https://orcid.org/0009-0008-4079-3910
Ben SlaterBiosciences Institute, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom.
Nour ShaheenDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.
Ariane E RhoneDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.ORCID https://orcid.org/0000-0002-5699-8733
Ryan CalmusDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.
Michael KritikosDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.
Sukhbinder KumarDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.
Brian DlouhyDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.
Hiroyuki OyaDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.ORCID https://orcid.org/0000-0002-1733-5478
Timothy D GriffithsDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.ORCID https://orcid.org/0000-0001-8066-4381
Aaron BoesDepartment of Psychiatry, University of Iowa, Iowa City, United States.
Nicholas TrappDepartment of Psychiatry, University of Iowa, Iowa City, United States.
Marcus KaiserNIHR Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
Jerome SalletStem Cell and Brain Research Institute, INSERM U1208, University of Lyon, Lyon, France.
Matthew I BanksDepartment of Anesthesiology, University of Wisconsin at Madison, Madison, United States.
Matthew A HowardDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.
Mario Zanaty *Department of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.
Chris Petkov *Department of Neurosurgery, University of Iowa, Iowa City, Iowa, United States.ORCID https://orcid.org/0000-0002-4932-7907

Funding

Project 5: ComputationalP50MH109429 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI STEPHANIE Ruggiano JONES · 2017 to 2026
$25.3M
HUMAN AUDITORY CORTEX PHYSIOLOGYR01DC004290 · NIDCD · UNIVERSITY OF IOWA · PI HOWARD, MATTHEW A. · 2000 to 2025
$13.7M
Laminar Circuit Motifs for Working Memory and Language Combinatorics: From Cells to SystemsU01NS137991 · NINDS · UNIVERSITY OF IOWA · PI Jeremy Greenlee, Christopher I Petkov · 2024 to 2026
$2.3M
Biotechnology and Biological Sciences Research Council PhD studentshipEngineering and Physical Sciences Research Council EP/W004488/1Engineering and Physical Sciences Research Council EP/X01925X/1Medical Research Council UKRI527National Science Foundation SBE-2342847NIDCD NIH HHS R01 DC004290NIH HHS R01DC004290NIH HHS U01NS137991NIMH NIH HHS P50 MH109429NINDS NIH HHS U01 NS137991Ruijin Hospital Guangci Professorship Program
6 · The paper itself

Abstract

Low-intensity transcranial ultrasound stimulation (TUS) is a promising non-invasive technique for brain stimulation and focal neuromodulation. Research with humans and animal models has raised the possibility that TUS can be biased towards enhancing or suppressing neural function. Here, we first collate a set of hypotheses on the directionality of TUS effects and conduct an initial meta-analysis on available healthy human participant TUS studies reporting stimulation parameters and outcomes (n

Indexed as

BrainHumansbrain stimulationhumanHumanlow intensity focused ultrasoundneuromodulationneurosciencenon-invasivetranscranial ultrasound

Identifiers

PMID42950002
PMCPMC13716386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.