Evidence map›Paper›PMID 42948769›Full record

ArticleActa pharmaceutica Sinica. B2026

Therapeutic targeting of the PRMT6/FOXK1 axis restores lipid homeostasis and ameliorates hepatic steatosis and steatohepatitis in mice.

Yang Sun, Tao Chen, Lei Zhang, Jinlin Duan, Junyan Xue, Wentao Huang, Jianzhong Di, Yonglong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yang SunLaboratory of Targeted Therapy and Precision Medicine, Department of Clinical Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Tao ChenDepartment of Biliary-Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Lei ZhangInstitute of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Jinlin DuanDepartment of Pathology, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200335, China.
Junyan XueLaboratory of Targeted Therapy and Precision Medicine, Department of Clinical Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Wentao HuangDepartment of Pathology, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200335, China.
Jianzhong DiDepartment of Bariatric and Metabolic Surgery, Department of General Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Yonglong ZhangLaboratory of Targeted Therapy and Precision Medicine, Department of Clinical Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is emerging as the leading cause of chronic liver disease, posing a global public health challenge without available therapeutic approaches. Protein arginine methyltransferase 6 is a type I PRMT that asymmetrically dimethylates arginine residues of a variety of substrates implicated in many diseases. However, its role in NAFLD pathologies has not been clarified. In this study, we show that PRMT6 is upregulated in NAFLD and NASH of mice and human patients.

Indexed as

Arginine demethylationFatty acid oxidationFOXK1GSK3α/βLipogenesismTORC1NAFLDNASHPRMT6

Identifiers

PMID42948769
PMCPMC13712363

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.