ArticleBiomedical reports2026
Association analysis of IL-6 polymorphisms and relevant biomarkers in patients with renal failure.
Article in Biomedical reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to clarify the relationship between polymorphisms present in the interleukin-6 (IL-6) gene (rs1800795 and rs1800797) and the susceptibility to chronic kidney disease (CKD), while concurrently examining critical biochemical markers (urea, creatinine, albumin, calcium, phosphate and glucose) alongside the levels of immunological factors [IL-6, tumor necrosis factor-α (TNF-α) and antinuclear antibodies (ANAs)]. A detailed investigation was carried out on a group of 51 subjects (22 male and 29 female subjects) who were 40-60 years old. The serum concentrations of IL-6, TNF-α and ANA were quantitatively evaluated using enzyme-linked immunosorbent assays, whereas the levels of various biochemical markers were determined by the Cobas 6000 analytical system. Genomic DNA was isolated and the IL-6 single nucleotide polymorphisms were genotyped by employing the PCR-restriction fragment length polymorphism methodology. The analysis of body weight showed notable differences between the male and female participants; however, other chemical markers did not indicate any sex-related variations. The correlation analyses illustrated moderate statistically significant relationships between albumin and calcium, together with an association between urea and phosphate, while the levels of IL-6, TNF-α and ANA portrayed a non-significant fluctuation. Analysis of the IL-6 gene showed that carriage of the rs1800795 C allele was associated with increased susceptibility to CKD, whereas rs1800797 was not significantly associated with CKD. Integrating genetic, immunological and biochemical data may improve understanding of CKD susceptibility, although validation in larger cohorts is required.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.