ArticleChinese herbal medicines2026
HXZQCG: A database of natural diverse components in polyherbal formulation HXZQ identified naringenin chalcone as a ligand of H
Article in Chinese herbal medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Huoxiang Zhengqi (HXZQ) is a classical polyherbal formulation used to treat gastrointestinal disorders. It exerts multi-targeted therapeutic effects, yet its phytochemical complexity hinders standardization and modern pharmacological development. This challenge is further exacerbated by the lack of comprehensive resources covering its diverse natural components, particularly as most previous research neglected peptides and small RNAs, which possess emerging therapeutic potential. There is an urgent need for novel research models to explore polyherbal formulations such as HXZQ. Here, we present the Huoxiang Zhengqi Component Galaxy (HXZQCG), a dedicated database for the HXZQ. HXZQCG integrates over seven million natural components through artificial intelligence-assisted mining, including 15 811 metabolites, 7 597 212 small peptides, and 152 342 small RNAs. To demonstrate its utility, we applied HXZQCG to screen for ligands of the histamine H
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