Evidence map›Paper›PMID 42942386›Full record

ReviewMedicina (Kaunas, Lithuania)2026

Cardiorenal Syndrome: Pathophysiology, Management, and the Challenge of Therapeutic Inertia.

Guido Gembillo, Vincenzo Calabrese, Luca Soraci, Lorenzo Lo Cicero, Manuel Scapellato, Rossella Messina, Maria Federica Ricca, Maria Rita Stancanelli, Andrea Corsonello, Domenico Santoro

Abstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guido GembilloUnit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.ORCID 0000-0003-4823-9910
Vincenzo CalabreseDepartment of Medicine and Surgery, "Kore" University of Enna, 94100 Enna, Italy.ORCID 0000-0001-6333-5009
Luca SoraciUnit of Geriatric Medicine, Italian National Research Center on Aging (IRCCS INRCA), 87100 Cosenza, Italy.ORCID 0000-0002-0171-3358
Lorenzo Lo CiceroPhD Program in Molecular and Clinical Medicine, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro" (PROMISE), University of Palermo, 90127 Palermo, Italy.ORCID 0000-0002-9112-5540
Manuel ScapellatoUnit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Rossella MessinaUnit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Maria Federica RiccaUnit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Maria Rita StancanelliDepartment of Medicine and Surgery, "Kore" University of Enna, 94100 Enna, Italy.
Andrea CorsonelloUnit of Geriatric Medicine, Italian National Research Center on Aging (IRCCS INRCA), 87100 Cosenza, Italy.ORCID 0000-0002-7276-3256
Domenico SantoroUnit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiorenal syndrome describes the clinical consequences of the bidirectional influence that cardiac and renal dysfunction exert on each other-a domain in which single-organ care proves insufficient. A 2024 meta-analysis estimated the pooled prevalence of chronic kidney disease among patients with heart failure at 49%. Across individual cohorts, this figure ranges between 30% and 60%, with the spread reflecting the population studied and the threshold used to define kidney disease. Among acute heart failure admissions, 64% of cases have an estimated glomerular filtration rate below 60 mL/min/1.73 m

Indexed as

Cardio-Renal SyndromeGlomerular Filtration RateHeart FailureHumansSemaglutideSemaglutidecardiorenal syndromechronic kidney diseasefinerenoneguideline-directed medical therapyheart failureimplementation sciencesemaglutideSGLT2 inhibitorstherapeutic inertia

Identifiers

PMID42942386
PMCPMC13706982

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.